Causes and risk factors
It is an autosomal dominant disorder. Only one defective gene from either of the parents can lead to the development of familial hypertriglyceridemia.
Clinical presentation
There are no specific symptoms. The affected person may show signs of heart disease from a very early age. Yellow deposits of fats called as xanthomas on the skin areas like soles of the feet, palms of hands, and eyelids, etc., are seen. There is hardening of arteries at a young age. Chest pain may occur. Signs and symptoms of coronary artery disease is seen.
Investigation
Medical history by the patient and clinical examination by the doctor helps in diagnosis. Blood tests like serum triglyceride levels, serum VLDL [very low-density lipoprotein] are advised. In case of family history, investigation of all family members is required to rule out the disease.
Treatment
This disorder cannot be cured completely, but a combination of healthy lifestyle and medications will help to reduce the risk of heart disease and other complications. Lifestyle measures include low-fat diet, regular exercise, loss of excess weight. Medications like statins, bile acid-sequestering resins, fibrates, and nicotinic acid contribute further to the treatment.
Other Modes of treatment
The other modes of treatment can also be effective in treating familial hypertriglyceridemia. Homoeopathy is a science which deals with individualization and considers a person in a holistic way. This science can be helpful in combating the symptoms. Similarly, the Ayurvedic system of medicine which uses herbal medicines and synthetic derivates is also found to be effective in treating familial hypertriglyceridemia.
